BRAIN DOCTORS

Brazil doctors poised for more uterus transplants

© Provided by AFP The Brazilian medical team behind the uterus transplant -- doctors Wellington Andraus (L), Luiz Carneiro (C) and Dani Ejzenberg (R) -- say they have two more women waiting to undergo the same procedure

Doctors in Brazil who brought about the first-ever birth with a uterus transplant from a dead donor say they have two more women waiting to undergo the same procedure.
"All the patients that were part of this initial group have already been selected. They have already undergone in-vitro fertilization," one of the physicians, Dani Ejzenberg, told AFP on Thursday.
"There are good quality embryos in storage, and now we are awaiting compatible donors so that the transplant can be done."
All three women would be part of the "proof-of-concept" experimental phase of the procedure. For it to be then offered more broadly to women as a medical option it would need approval from Brazilian health authorities.
Very happy child
Ejzenberg, a gynecologist at the University of Sao Paulo's teaching hospital, was part of the team that this week revealed the success of their experimental operation carried out in September 2016.
That operation involved a uterus from a 45-year-old woman who died of a stroke being transplanted into the body of a 32-year-old recipient who was unable to conceive. The recipient was born without a uterus because of a rare syndrome, according to their account published in The Lancet medical journal.
Fertilized eggs were implanted in the uterus seven months later, after a cycle of drugs to suppress organ rejection.
On December 15, 2017, the baby girl was born.
Related slideshow: News in pictures (Provided by Reuters)

"She is a very happy child and the mother too feels very fulfilled with this breakthrough," Ejzenberg said.
"On December 15 the baby will turn one year old," he said, adding that she was showing "completely normal development from both motor and neurological points of view."
Professor Luiz Carneiro, who headed the transplant team, explained that he and his colleagues were proud of the fact that they coaxed life out of their groundbreaking procedure.
"We as transplanters are used to transplant organs, and in that sense we saw that it was an opportunity for a very different focus in that we were generating life from this," he said.
The transplanted uterus in the woman was removed during the C-section birth, allowing her to stop taking immunosuppressive drugs.
Lack of live donors
Before the Brazilian experiment, the only options available to women with so-called uterine infertility were adoption or the services of a surrogate mother.
The first successful childbirth following uterine transplant from a living donor took place in September 2013 in Sweden, and there have been 11 others since then.
But there are far more women in need of transplants than there are potential live donors, so medical teams in different countries have been working to see the viability of using uteruses from deceased donors.
Ten unsuccessful attempts had been made -- in the United States, the Czech Republic, and Turkey -- before the breakthrough first live birth in Brazil.

How Do I Fulfill My Dream?

1.Select a dream to fulfill. Some of us have so many dreams swirling in our minds, we don’t know where to start… while others of us are unable to put our finger on even one. Whether the decision be to write a book, run a marathon, buy a home, or find true love, fulfillment always starts with the intentional identification of one single goal and the heartfelt conviction to accomplish it. Take some time. Pick one. And then, set out to accomplish it.

2. Believe it is achievable. Unfortunately, too many people will never accomplish their dreams because they simply refuse to believe in themselves. Optimism is absolutely required for dream fulfillment and life enjoyment. If you don’t have natural self-confidence, make finding it your first dream to accomplish. I suggest, “How to Believe in Yourself: A Four Step Plan.” If you do have self-confidence, begin to specifically direct it towards your chosen goal.

3. Ask for help. People have gone before you. Learn as much as you can from them. When I decided to run a marathon, I read How to Run Your First Marathon and talked to my co-worker Carole almost every single week. When I decided to write an ebook, I talked to Jeramiah (technology), Martha (editing), and Jana (title/outline). Each had information that I needed and played a significant role in helping me accomplish my dreams. Don’t let your pride be the one obstacle that keeps you from them. Instead, humble yourself and ask for help.

4. Adjust your life as necessary. By definition, if you have not accomplished your dream yet, you’ll need to adjust your lifestyle to accomplish it. And while some of the adjustments may be major, they always start small:

• Running a marathon starts with running one mile.
• Writing a book starts with deciding on a subject.
• Clearing your home of clutter starts with cleaning one drawer, closet, or room.
• Losing 50 pounds starts with changing one meal.
• Buying a home starts with saving one dollar.

Fulfilling your dreams will require you to change your lifestyle – one small step at a time. And while there may be a large number of steps to take, the good news is that the first one is completely achievable… and so is the second…

5. Set a deadline. Deadlines force our hand and call us to action. Therefore, it is absolutely essential to pick a realistic timeline and get moving. Buy a home in the next 3 years. Fix your marriage in the next year. Lose 20 pounds in the next 6 months. Or start a blog in the next 30 days. Find a calendar, a red marker, and a day. Go ahead, circle it. After all, a dream without a deadline is just a wish.

6. Tell others. I have found limitless encouragement by sharing my dreams with others. The number of people cheering for me automatically doubles. Soon, it triples. Suddenly, I’m not just trying to let myself down, but I’m trying to not let my friends down as well. And the cost of failure has just increased.

7. Stay focused. By nature, dreams will require perseverance. There will be successes and failures along the way. Those who persevere through the failures will accomplish their dreams. Those who give up will return to step #1. And if you’ve gotten this far, why would you want to start over? Instead of allowing failures to kill your dreams, use them to refocus you and your resolve.

On a side note, I realize all too well that the circumstances of life ebb and flow. I humbly recognize that the positive circumstances of my life this past year have allowed these dreams to be accomplished. One major illness, accident, or misstep could have derailed any of them listed above. If you currently find the circumstances of life derailing you from reaching your dreams, let me encourage you. Don’t lose hope. Just redirect your dreams.

I have a postcard taped to my wall. It says, “The secret to making your dreams come true is to wake up.” Well, how? Leading off with selecting a dream (step 1), each of these tips is a pull out of sleep. Personally, I’ve struggled with asking for help (step 3) and starting small (step 4). I find it both hard, and essential, to remember that people do like to help, and that most thousand-mile walks had a humble first hour.

JAMB FLASHLEARNERS

How To Prepare And Pass Jamb In Less Than Two Weeks

If you are in as situation where you still have a whole lot to cover and Jamb examination is less than one month, this article is for you. Stop whatever you are doing and read this life changing article on two weeks Jamb solution to the end.

Now, you may be wondering, is it possible to still prepare and pass very well when Jamb is already around the corner? It is very possible. As a matter of fact, so many persons have done it in the past.

What matters in any examination is how you prepare when the exam is very close. It is better to start serious reading two weeks to the exam than to stop reading a week to the exam.

This brings us back to the title, “How To Prepare And Pass Jamb In Two Weeks”. Take a glass of water and let me teach you how to engage in emergency preparations for Jamb.

Steps To Prepare And Pass Jamb In Two Weeks

Do you really want to prepare and pass Jamb in two weeks, the following tips will help you achieve that:

1. Study with full insight.
2. Make Use Of Adrenaline.
3. Don’t Read Big Materials.
4. Read And Revise.
5. Use Past Questions

I will now break down the points so that you will get the full understand of the message I am trying to pass across. Trust me, it is going to be very easy for you to understand and apply.  All the points are important, however, number five is the real gist. Do not forget the number five on my list.

(1) Study With Full Insight

Since Jamb is now very close, you do not need to pay attention to every detail.

As you read, pick out the important points and neglect the rest. This will improve the rate at which you cover topics.

Stories in the textbook are to make you feel more comfortable and as well make the text interesting. They do not come out in the exam.

Now you may be asking, what about the recommended novel for Jamb use of English? It is true that the novel contains stories. Do not waste your time reading the Jamb novel. Focus on other subjects and topics.

However, pay more attention to the dates, characters and location in the novel. Questions there will come in the form of where, what, when and how.

During these few days to the exam, do not assume that you know any topic. Ensure that you visit every topic as fast as possible.

Do not waste time on any topic. Jot down the key points very fast and go back to them later for better understanding.

See Also: How to answer Jamb questions with the speed of light.

(2) Make Use Of Adrenaline

As Jamb examination date draws closer, your zeal to read reduces. When it is now finally two weeks to the exam, your zeal to read increases.

Do not waste this sudden increase appetite to read on social media. Go to your closet and read like never before. It is time to spend a high quality time with your books.

If I may ask, when last did you spend 15 hours straight with your books?

Two weeks to the exam, the power to remember everything you read in the exam hall builds up. You will not forget anything you study easily in this period. Take advantage of this to study as many topics as possible.

Many Jambites are fond of reading and chatting simultaneous. This is not good for you, especially when you have a whole lot to cover within the limited time. Don’t Facebook but Face Your Book.

Have confidence in yourself. There is no way you will fail Jamb. Forget what you hear about Jamb. If I could pass Jamb and gain admission into my school of choice, what makes you think that you cannot do the same?

(3) Don’t Read Big Materials

The books recommended by Jamb are usually very bulky. You don’t have to study them when the examination is already knocking at your door.

Get textbooks that are straight to the point. There are books you can finish within two days. This doesn’t mean that they are of lower quality. The only thing is that they contain only the relevant points.

Example of such textbook is QUICK REVIEW IN CHEMISTRY. You can actually finish the book in two days and score 90+ in Jamb chemistry. There are such simplified books for every subject.

If you have sound background in English, nothing should stop you from passing Jamb use of English.

Comprehension may want to take your time, but I have dealt with how to answer jamb comprehension passages in 10 minutes. Click here to read my famous article on Jamb reading comprehension.

(4) Read And Revise

This point is very easy. Read and go over it after sometime.

As the name implies, ensure to put down very important points as you study. Then try to revise all the points when it is two days to the exam.

This is to ensure that you don’t struggle to remember in the exam hall. The rhema just flows without stress.

It is possible that you may not really understand some ideas passed in the topic. Revision gives you better understanding.

Revision is very effective and powerful. Do not fail to revise.

(5) Use Past Questions

Welcome on board. The fastest way to prepare and score very high in Jamb is the use of Jamb past questions.

Get the past questions for your four Jamb subjects and study along with them.

Start solving past questions from the year 2005. Make sure you solve and understand everything.

You should be able to solve and understand 8 years past questions within a week and two days.

Consult Google or your textbook for any question that is not clear. This is funny,  but you will have to cram what refuses to enter.

Generally, you don’t have to cram past questions. Try as much as possible to get the full picture.

As simple as this may be, it is capable of making you score 350+. Follow these guide and you will surely come back to testify. Mark my words.

Note: You don’t only study Jamb past questions because it would be repeated word-for-word. You study past questions so as to operate at the same frequency with Jamb. That’s to say, it makes you attain Jamb standard and no question surprises you in the hall.

Answer Exam Questions Faster With These 5 Tricks

1. See The Light:

To answer exam questions with the speed of light, you need to first see the light.

Light in this context speaks of reading and understanding the nature of questions you will likely encounter in the exam.

You will never answer questions very fast under the topics you are not good at.

Make sure you cover all the topics recommended in the exam syllabus. Go through it over and over again.

Solve as many questions as possible. Any topic you read, ensure to answer at least 20 questions. That should be your minimum.

The average number of questions you should attempt under every topic should be a hundred (100).

Don’t just answer them, make sure you really understand them.

Solve problems to the extent that you will tell yourself, “there is no question I cannot answer under this topic as far as this exam is concerned”.

With this, you have seen the light (prepared for the examination).

2. Practice With The Speed Of Light:

Yes! the second step to answer exam questions with the speed of light is to practice and answer likely exam questions with the speed of light. I will make this very simple.

Do you still remember the saying that charity begins at home? They never said that charity begins in the house. They made the home factor very clear.

When you are able to achieve the speed of sound at home, then it becomes very easy to achieve the speed of light in the exam hall.

As you practice questions, time yourself in minutes. As time goes on, begin to solve questions in seconds and milli-seconds.

The truth is that nothing is impossible. This is how I prepare for major exams.

I have been in an exam situation where I didn’t solve 40% of the questions before picking the right answers.

The more you solve with pen, your brain gets matured enough to process and manufacture answers even before you write anything down.

3. Revise Everything Before The Exam:

One of the factors that can slow you down in the exam hall is forgetting what you have read.

The more you forget things in the hall, the more your speed drops. In some cases, your speed can drop for that of sound to the speed of snail.

To overcome this factor, you need to revise everything. This is what I called reverse flash in my article on the secrets of successful students.

Never be too busy to revise all over again. Remember, if you are not humble enough, you will stumble. Keep calm and go through it all over.

4. Read The Exam Questions With Full Confidence:

Your confidence determines your competence. The more confidence you command, the greater the response from the you-in-you.

The you-in-you is the real you. It is the giant in you that takes only possibility for an answer.

Do not read the questions with fear. Attempt the questions the way you normally solve questions at home.

Do not be too conscious of time when answering exam questions. This is to ensure that you don’t make mistakes. All you need is to remain in the speed of light.

When you combine the mass of the exam questions with your speed of light, your momentum builds up. This momentum will be in the direction of success and high score.

The exam questions are afraid of you. So, you don’t have any valid reason to be afraid.

5. Start From Know To Unknown:

Yes! start from the simpler questions.

There are questions that cannot be solved easily and as well those that do not need to be solved.

Solve the questions that will take you milli-seconds first, then the ones that will take you seconds before attempting the questions that consumes minutes.

JAMB 2019 Registration Begins October - What you need to know for now

The Registrar of JAMB, Prof. Ishaq Oloyede, has confirmed that Registrations for the 2019 JAMB UTME will begin by the end of October. This directly translates that 2019 JAMB Forms should be on sale before 31st October, 2018. This was confirmed while he was fielding questions from Journalists in Abeokuta.

Prof. Oloyede had earlier stated that the cost of the JAMB Registration Forms will be left for FG to ultimately decide. He then added that; “We are not interested in the money. We are interested in having adequate preparation for those who are genuine students".

The actual dates for conducting the 2019 UTME is yet to be announced, but the Registrar has assured the public that it would not clash with the coming 2019 Elections.

In the meantime, you can Check 2019 JAMB Brochure, the 2019 JAMB Syllabus or simply Start to Practice 2019 JAMB CBT for Free.

For candidates who are still expecting their names on of the various admission lists, you're urged to always check your admission status on JAMB Caps. Sales of 2019 JAMB form does not put an end to Admissions for 2018/2019. In fact, in some schools, and based on Myschool experience, admissions are likely to go on even till next year.

For those who are already sure they will be writing the 2019 UTME, please keep visiting this website or keep checking The Free Myschool App to stay up to date on when the registration begins.

Schools, Institutions, Tutorial Centres, Business Centres & Cafes can start setting up their CBT Centres to become JAMB CBT Agents and Training Centres to help train students for the upcoming exams. For details on how to proceed, please click here.

Once the JAMB Registration for 2019 Begins, we will publish it here on Myschool, and give you step by step details on how to successfully proceed with your registration.

History of Pharmacy, Pharmacy Education, Career and Ethics in Nigeria

Just as it is in other parts of the world, the history of pharmacy in Nigeria is old, though largely unrecorded. Medical knowledge was largely kept by traditional healers. Information on healing including the materials and the methodologies were passed down verbally from generations and sometimes lost due to death. It is only perhaps from the last half of the 19th century, with the introduction of Western education that some wise elders started dictating such knowledge to their younger ones for posterity.

Before the advent of the early European missionaries, the major source of healing the sick was through the traditional healers, who used clay, plants and animal parts, or supernatural means (or combinations thereof) to bring about healing to their patients.

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Early Years of European Pharmacy Practice

This era covers the period from the late 19th century to the first few decades of the 20th century. Pharmacy education during this period started with training of Nigerians in dispensing through apprenticeship under physicians, to prepare simple solutions and mixtures and subsequently either serving as dispensers in the hospitals or opening medicine shops to serve Nigerian community. An example of such early shops was that of Mr Richard Zaccheus Bailey, which was opened in 1887 along Balogun Street in Lagos.

Later on experienced dispensers and reputed pharmaceutical companies were allowed to train others. Again, Mr Bailey was an example of such early trainer of dispensers. With time, apprenticeship training in hospitals under physicians became more formal and regular. By the beginning of the 3rd decade of the 20th century (i.e the 1920’s), it became clear that the apprenticeship programme could no longer meet the need for pharmacy services in Nigeria, and preparations were made through legislation to open school of pharmacy for training of dispensers. This plan materialized through the establishment of a School of Pharmacy at Yaba, Lagos for the purpose in 1925.

Hospital Pharmacy Practice

A clear majority of the “pharmacists” in the early part of this era were actually “dispensers”. The hospitals or dispensaries were managed under the supervision of the medical officers in charge of such hospitals or dispensaries. There were only four hospitals in Nigeria as at 1900. These hospitals were located in Lagos, Asaba, Abeokuta and Calabar, three of which were government hospitals and one, a mission (Catholic) hospital. These hospitals used a common hospital formulary. There were also a number of mission medical set-ups before this date in some coastal towns, which could not be described as hospitals. However, there was a steady growth in the number of hospitals both government and mission between 1900 -1960.

Community Pharmacy Practice

In community practice, the first medicine shop was opened in 1887 by Mr Richard Zaccheus Bailey in present-day Balogun Street of Lagos State. It was primarily to cater for his European clients and a few African elites. Other retail pharmacies did not come into existence until the 1920’s and much later. The West African Drug Company Ltd was established in 1924, while commercial Medicine stores (by Chief S. T. Hunponu-Wusu and Mr Robert Olatunji Adebowale) and Phillips Medicine Stores (by Thomas King Ekundayo Phillips) were established in the 1940’s all in Lagos. Several years went by before retail pharmacies were opened in the towns of the old Western, Eastern and Northern regions of Nigeria. By the end of 1960, as many as 150 community pharmacy shops had been established while a total number of registered pharmacists (many of who were not in community or general pharmacy practice) was 542.

 

Industrial Pharmacy Practice

Industrial pharmacy was evident with the arrival of May and Baker in 1944, Glaxo and Pfizer in 1954. These pharmaceutical companies were mainly into importation and marketing of pharmaceuticals. Large-scale drug production began in the 60s involving government agencies, multinational companies and private entrepreneurs. Presently, there are more than 115 registered pharmaceutical manufacturers in Nigeria. These companies manufacture various pharmaceutical dosage forms cutting across various therapeutic classes. In addition to providing dependable high-quality pharmaceutical products to medical professionals and patients in various communities in Nigeria and West Africa, they have also contributed greatly to the economic growth of the nation.

Click to view a comprehensive list of drug manufacturing companies in Nigeria

Notable Pioneers of Pharmacy in Nigeria

1. Mr Richard Zaccheus Bailey (1829-1911)

Mr Richard Zaccheus Bailey, popularly known as the doctor was the first man to open a pharmacy in Nigeria in the year 1887 along Balogun Street, Lagos having obtained a license from the Governor-in-Council to do so. He also trained many dispensers – Alfred Philip, Julius Apena, Nelson Cole, S. R. Macauley, Moses Da-Roche and John Caulcrick, all of who later trained as physicians.

2. Mr Emmanuel Caulcrick

According to official records, Mr Emmanuel Caulcrick was the first registered Nigerian pharmacist. He was registered on the 1st September 1902. He later opened a medicine store in Lagos.

 

3. Thomas King Ekundayo Phillips (1884 – 1969)

Thomas King Ekundayo Phillips was born in 1884 to the Bishop and Mrs Charles Phillips. He attended the Government Training School for Dispensers, where he trained and qualified as a Chemist and druggist. Thomas King Ekundayo Phillips opened a chemist store – Philips Medicine Store in Faji Market, presently Tinubu Square in Lagos State. He subsequently trained as an optician. He was also the first president of Pharmaceutical Society of Nigeria (PSN) (1947 – 1951).

4. HRH. Oba John Adetoyese Laoye (1899 – 1975)

HRH. Oba John Adetoyese Laoye was born in 1899. He trained as a dispenser through hospital apprenticeship that he competed in 1917. He served as a government dispenser in many towns in Nigeria including Kano, Kaduna, Jos, Ibadan, Akure, Sapele, Maiduguri, Benin, Warri and Forcados. He was enthroned in 1946. He was a founding father of the Nigerian Western House of Chiefs (1952).

5. Sir kofo Abayomi

Sir kofo Abayomi was one of the early dispensers, who trained through apprenticeship. He served in several hospitals. He was also enlisted in the army as a sergeant dispenser during the First World War where he gained valuable experience with and worked under some European pharmacists and Physicians.

6. Prof. Dr Cletus Nzebunwa Aguwa

Prof. Dr Cletus Nzebunwa Aguwa was the first academic clinical pharmacist to be employed in Nigeria. He was also the first professor of clinical pharmacy in the entire black Africa.

Others notable pharmacists who are qualified to be numbered include, Chief S. T. Hunponu-Wusu, Mr. Azariah Olusegun Ransome-Kuti, , Mr Robert Olatunji Adebowale, Mr. Afolabi, I. Kinoshi, Mr. Peter Etim Archibong, Mr. D. A. Pratt, Dr. Gordon Taylor, Mr. J. P Marquis, Pa Peter Omar Ishaku, Ahaji Adamu Bako Dikko, Chief (Mrs.) Ekanem Bassey Ikpeme etc.

Pharmacy education in Nigeria

Pharmacy education in Nigeria passed through five developmental stages viz:

1. Training of dispensers through apprenticeship (1887 – 1923)
2. Training of dispensers through formal schools of pharmacy e.g., School of Pharmacy Yaba, School of Pharmacy, Zaria.
3. Training of chemists and druggist (1927 – 1972) in School of Pharmacy, Yaba and Zaria and Nigerian College of Arts, Science and Technology, Ibadan.
4. Training of pharmacists at Bachelor Degree level (1963 to date).
5. Training of pharmacists at Doctor of Pharmacy Degree level (2016 to date).

Pharmacy career prospects

Pharmacy profession offers quite a lot of career opportunities and they include:

• Hospital pharmacy
• Community pharmacy
• Wholesale pharmacy
• Industrial pharmacy
• Veterinary pharmacy
• Administrative/ Organizational pharmacy
• Pharmacy journalism
• Pharmacy education/ the academia

Code of ethics for pharmacists

Pharmacy is a professional course that deals directly with humans and is thus governed by rules and ethical codes that should at all times be strictly adhered to. His professional responsibility is shown towards patients, his colleagues, his community and also to himself.

Pharmacist’s responsibilities to his patients and his community

• He should be objective in his dealings with patients placing their good and welfare before financial gains.
• He should not discriminate among patients.
• He should respect patients’ right of confidentiality.
• His professional services should be in the overall interest of the community.

Pharmacist’s responsibilities to his colleagues and service

• He must cooperate with other colleagues in all professional duties.
• He should seek fair and reasonable remuneration for his services.
• He should provide pharmaceutical efficient services in the organization where he works.
• He must not agree to practice under conditions and terms that will interfere with his professional duties.
• All relevant documents concerning poison and classified drugs should be duly filled and kept safe.

Pharmacist’s responsibilities to self

• He should try to keep himself updated with current trends and knowledge of drug therapy to ensure competence at all times.
• His manner of life should be professional and not be a disgrace to the profession.

Pharmacy premise

• The location must be in accordance with the regulations of Pharmacists Council of Nigeria (PCN).
• The premise both internally and externally should reflect professional character.
• The pharmacist should at all times be seen at the premise offering professional services.
• He should avoid drug and service advertisement contrary to PCN regulations.

The 12 Best Food Sources of Sulfur:

Sulfur is a mineral that is present in every cell of the body.  It plays a key role in liver metabolism and the function of the joint cartilage and keratin of the skin & hair. It is also critical for metabolism and anti-oxidant defense systems that protect the aging patterns of the brain.  Some of the healthiest cultures in the world have the highest levels of sulfur in their diet while the US has some of the lowest levels (1).

Icelanders are known for their low rates of depression, obesity, diabetes, and heart disease (1).  Researchers are attributing much of this to the line of volcanoes that formed the island nation.  These volcanoes are full of sulfur ash which blankets the soil after an eruption. This enriches the ground and makes drinking water, produce, and meat products contain a dense supply of this key compound.

Sulfur: Critical for Optimal Health:

Over the last 2 decades, the US farming industry has shifted into a highly technologized mega farms.  These farms are entirely focused on producing high yield per acre and thus they have depleted many vital nutrients such as sulfur from the ground. These farmers also apply artificial fertilizers to the soil.  These fertilizers are enriched in phosphates and very low in sulfur.  These excess phosphates interfere with the absorption of this and many other key compounds.

Sulfur amino acids are extremely important for the maintenance and integrity of the cellular systems. They strongly influence the ability to manufacture glutathione and the capacity to neutralize free radicals, reactive oxygen species and detoxify poisonous compounds.  Could your diet be deficient in these critical amino acids?

Sulfur Boosts Anti-Oxidants:

There are 2 sulfur containing amino acids; cysteine and methionine.  They are not stored in the body.  Any dietary surplus is oxidized to sulfate and excreted in the urine or is stored as glutathione (GSH). Glutathione is one of the bodies most important anti-oxidants.  Lowered GSH levels are associated with degenerative disease, lowered immunity, & toxic build-up (2, 3, 4).  Cysteine levels appear to be the rate limiting factor for the synthesis of GSH (5).

The internal triage system of the body typically spares the brain since it is the most critical organ. However, in cases of low sulfur containing amino acids the brain will deplete its stores of GSH in order to maintain cysteine levels.  This reduces the brain’s antioxidant defenses and accelerates the degenerative processes.

Sulfur Helps Repair the Joints:

Sulfur plays a very important role in joint, cartilage, skin & blood vessel formation through the glycosaminoglycan (GAG) compounds.  Some of the familiar GAG compounds include glucosamine, heparan sulfate and chondroitin sulfate.  When sulfur levels are depleted the body is unable to replace the old and inferior GAG molecules in the joints.  With inadequate repair materials the joints, blood vessels, & skin cells suffer and degenerate faster.

Sulfation is a critical detoxification pathway in the liver. This is particularly necessary to detoxify pharmaceutical drugs such as acetaminophen.  The sulfation process of detoxification depletes the body of sulfur containing amino acids (6).  This is why individuals taking pharmaceutical medications need even more dietary sulfur.

Best Food Sources of Sulfur:

The best plant foods for this key compound are found in the Allium family which is high in allyl sulfides and sulfoxides. These include onions, garlic, leeks, shallots, & chives.  The cruciferous vegetable family has sulfur containing isothiocyanates that are potent cancer fighters. These foods include broccoli, cauliflower, cabbage, brussel sprouts, radishes, watercress, kale, & collard greens.

Animal foods rich in sulfur containing amino acids include organic eggs, wild-caught fish, & grass-fed beef. Raw dairy from grass-fed cows (particularly sulfur rich grass) is a great source of these key amino acids.  Bone Broth protein is also a rich source of a wide array of important amino acids as well.

Sulfur Rich Meal Plan:

These are some ideas to help you get a lot of sulfur rich nutrients into your system each day.

Breakfast:     Option 1:  Protein shake with almond milk, berries and bone broth protein – you could also put an avocado in this to make it thicker and creamier and add more sulfur compounds.    Option 2:  Veggie omelet with 3 eggs and 2 oz of grass-fed cheese and onions, tomatoes and kale inside

Lunch:  Green juice with bok choy as the water rich vegetable and turnip or mustard greens as the chlorophyll rich greens.  Have this with an avocado salad with grass-fed cheese and/or organic chicken or if you want to eat lighter you could do guacamole and flax crackers

Dinner:  Steamed broccoli and cabbage (could also do brussel sprouts, cauliflower, asparagus, etc) with grass-fed butter smeared all over.  Grilled garlic lemon chicken cooked in coconut oil.  Top with herbs on both and you may want to include a small sweet potato with grass-fed butter and cinnamon on top.  Instead of the sweet potato, you could always do double veggies.

 

Derek Lowe is perhaps America’s best-known medicinal chemist. That may not sound like much, but in a quiet field where most people go through their entire careers without discovering a marketable drug, it’s tough to make a name for yourself.

In 2002, Lowe became the first industry insider to start a blog — and he’s been enthusiastically at it ever since, writing on his blog In the Pipeline between experiments at Vertex Pharmaceuticals in Boston. STAT spoke with Lowe about Internet trolls, his love for chemical reactions, and his new book on the history of chemistry.

Do you make a living from the blog?

If I were trying to make a living off the blog, I’d be eating weeds out of the backyard.

Why did you start writing it 14 years ago?

Reading other people’s blogs, I realized the barrier to doing this was minimal, so I kind of jumped into it.

Has the blog helped you professionally?

The blog has forced me to keep up with the scientific literature, both in drug discovery and associated areas. That helped me scientifically, and of course, it’s given me a lot of visibility, which has been no harm, either.

But you can’t blog about your own research?

My current scientific interests are mostly proprietary. I’m doing a lot of really interesting work that, most frustratingly, I cannot say a word about.

Were you the typical chemistry kid blowing things up in the basement?

I did have some chemicals that were in a higher oxidation state than an 8- or 9-year-old should have, yes.

What appeals to you about chemistry?

I like being the first to find this stuff out. When I make a compound no one else has ever made, even these days, I think, “There it is, never in the universe before, until I did it with my hands.” It’s ego partly, and it’s just sheer curiosity.

But it requires tremendous patience, no?

I’ve been doing this for 27 years, and I have never once put a drug into a pharmacy. I tell people: “If you want to know why your prescriptions cost so much, it’s me.” I’ve done nothing but spend money the entire time.

In addition to writing about chemistry, you’ve included recipes on your blog for pecan pie, lime sorbet, cornbread, and other foods. Do you see a lot of overlap between cooking and chemistry?

Never trust an organic chemist who can’t cook.

Your blog is now on Science Translational Medicine’s website. Has your audience shifted?

It’s the same motley crowd as ever. It gives me more visibility, so the motley crowd grows larger.

Do you get a lot of trolls?

The comments section has always been a point of pride to me, even though I had nothing to do with it. The people who show up and comment a lot are very knowledgeable. They don’t go around making comments about each others’ mothers.

Do you ever get tired of writing about failure in drug development?

I’ve seen people who couldn’t stand their ideas not working. If you can’t stand your ideas not working, you shouldn’t be in science.

Are you leaving a legacy for science?

I’m leaving a huge pile of stuff on the Internet for free. Now I have a book out and I wouldn’t mind writing another one. I would love to leave a scientific legacy. I’ll try the best I can, but the universe has a big say in this, too.

Motivational Quotes to Help You Achieve Your Dreams

 

Need a quick dose of inspiration? Need a quick surge in motivation? You'll definitely find it here ...

• "The best time to plant a tree was 20 years ago. The second best time is now." --Chinese proverb
• "If you set your goals ridiculously high and it's a failure, you will fail above everyone else's success." --James Cameron
• "Success usually comes to those who are too busy to be looking for it." --Henry David Thoreau
• "If you are not willing to risk the usual, you will have to settle for the ordinary." --Jim Rohn
• "Stop chasing the money and start chasing the passion." --Tony Hsieh
• "All our dreams can come true if we have the courage to pursue them." --Walt Disney
• "If you are willing to do more than you are paid to do, eventually you will be paid to do more than you do." --Anonymous
• "Success is walking from failure to failure with no loss of enthusiasm." --Winston Churchill
• "Whenever you see a successful person, you only see the public glories, never the private sacrifices to reach them." --Vaibhav Shah
• "Opportunities don't happen. You create them." --Chris Grosser
• "Try not to become a person of success, but rather try to become a person of value." --Albert Einstein
• "It is not the strongest of the species that survive, nor the most intelligent, but the ones most responsive to change." --Charles Darwin
• "Great minds discuss ideas; average minds discuss events; small minds discuss people." --Eleanor Roosevelt
• "The best revenge is massive success." --Frank Sinatra
• "I have not failed. I've just found 10,000 ways that won't work." --Thomas Edison
• "A successful man is one who can lay a firm foundation with the bricks others have thrown at him." --David Brinkley
• "The whole secret of a successful life is to find out what is one's destiny to do, and then do it." --Henry Ford
• "What seems to us as bitter trials are often blessings in disguise." --Oscar Wilde
• "The distance between insanity and genius is measured only by success." --Bruce Feirstein
• "Don't be afraid to give up the good to go for the great." --John D. Rockefeller
• "Happiness is a butterfly, which when pursued, is always beyond your grasp, but which, if you will sit down quietly, may alight upon you." --Nathaniel Hawthorne
• "There are two types of people who will tell you that you cannot make a difference in this world: those who are afraid to try and those who are afraid you will succeed." --Ray Goforth
• "Start where you are. Use what you have. Do what you can." --Arthur Ashe
• "People ask, 'What's the best role you've ever played?' The next one." --Kevin Kline
• "I find that the harder I work, the more luck I seem to have." --Thomas Jefferson
• "The starting point of all achievement is desire." --Napoleon Hill
• "Success is the sum of small efforts, repeated day in and day out." --Robert Collier
• "If you want to achieve excellence, you can get there today. As of this second, quit doing less than excellent work." --Thomas J. Watson
• "All progress takes place outside the comfort zone." --Michael John Bobak
• "You may only succeed if you desire succeeding; you may only fail if you do not mind failing." --Philippos
• "Courage is resistance to fear, mastery of fear--not absence of fear." --Mark Twain
• "Only put off until tomorrow what you are willing to die having left undone." --Pablo Picasso
• "We become what we think about most of the time, and that's the strangest secret." --Earl Nightingale
• "The only place where success comes before work is in the dictionary." --Vidal Sassoon
• "Though no one can go back and make a brand-new start, anyone can start from now and make a brand new ending." --Carl Bard
• "I find that when you have a real interest in life and a curious life, that sleep is not the most important thing." --Martha Stewart
• "Twenty years from now, you will be more disappointed by the things that you didn't do than by the ones you did do. So throw off the bowlines. Sail away from the safe harbor. Catch the trade winds in your sails. Explore. Dream. Discover." --Mark Twain
• "The first step toward success is taken when you refuse to be a captive of the environment in which you first find yourself." --Mark Caine
• "Whenever you find yourself on the side of the majority, it is time to pause and reflect." --Mark Twain
• "The successful warrior is the average man, with laserlike focus." --Bruce Lee
• "Keep on going, and the chances are that you will stumble on something, perhaps when you are least expecting it. I have never heard of anyone ever stumbling on something sitting down." --Charles F. Kettering
• "If you genuinely want something, don't wait for it--teach yourself to be impatient." --Gurbaksh Chahal
• "You can't connect the dots looking forward; you can only connect them looking backward. So you have to trust that the dots will somehow connect in your future. You have to trust in something--your gut, destiny, life, karma, whatever. This approach has never let me down, and it has made all the difference in my life." --Steve Jobs
• "If you want to make a permanent change, stop focusing on the size of your problems and start focusing on the size of you!" --T. Harv Eker
• "Successful people do what unsuccessful people are not willing to do. Don't wish it were easier; wish you were better." --Jim Rohn
• "The No. 1 reason people fail in life is because they listen to their friends, family, and neighbors." --Napoleon Hill
• "In my experience, there is only one motivation, and that is desire. No reasons or principle contain it or stand against it." --Jane Smiley
• "Success does not consist in never making mistakes but in never making the same one a second time." --George Bernard Shaw
• "I don't want to get to the end of my life and find that I lived just the length of it. I want to have lived the width of it as well." --Diane Ackerman
• "Motivation is what gets you started. Habit is what keeps you going." --Jim Ryun
• "Our greatest fear should not be of failure ... but of succeeding at things in life that don't really matter." --Francis Chan
• "If you don't design your own life plan, chances are you'll fall into someone else's plan. And guess what they have planned for you? Not much." --Jim Rohn
• "Nobody ever wrote down a plan to be broke, fat, lazy, or stupid. Those things are what happen when you don't have a plan." --Larry Winget
• "To be successful, you must accept all challenges that come your way. You can't just accept the ones you like." --Mike Gafka
• "Be content to act, and leave the talking to others." --Baltasar
• "You may have to fight a battle more than once to win it." --Margaret Thatcher
• "Be patient with yourself. Self-growth is tender; it's holy ground. There's no greater investment." --Stephen Covey
• "I owe my success to having listened respectfully to the very best advice, and then going away and doing the exact opposite." --G.K. Chesterton
• "Many of life's failures are people who did not realize how close they were to success when they gave up." --Thomas A. Edison
• "The greater the artist, the greater the doubt. Perfect confidence is granted to the less talented as a consolation prize." --Robert Hughes
• "What would you attempt to do if you knew you would not fail?" --Robert Schuller
• "Always bear in mind that your own resolution to success is more important than any other one thing." --Abraham Lincoln
• "Successful and unsuccessful people do not vary greatly in their abilities. They vary in their desires to reach their potential." --John Maxwell
• "Would you like me to give you a formula for success? It's quite simple, really: Double your rate of failure. You are thinking of failure as the enemy of success. But it isn't at all. You can be discouraged by failure or you can learn from it, so go ahead and make mistakes. Make all you can. Because remember, that's where you will find success." --Thomas J. Watson
• "Logic will get you from A to B. Imagination will take you everywhere." --Albert Einstein
• "Success is just a war of attrition. Sure, there's an element of talent you should probably possess. But if you just stick around long enough, eventually something is going to happen." --Dax Shepard
• "My tombstone? I'm thinking something along the lines of, 'Geez, he was just here a minute ago.'" --George Carlin
• "Dream as if you'll live forever, live as if you'll die today." --James Dean
• "Doing what you like is freedom. Liking what you do is happiness." --Frank Tyger
• "Be happy with what you have. Be excited about what you want." --Alan Cohen
• "Life is a journey, and if you fall in love with the journey, you will be in love forever." --Peter Hagerty
• "I've learned that people will forget what you said, people will forget what you did, but people will never forget how you made them feel." --Maya Angelou
• "Much of the stress that people feel doesn't come from having too much to do. It comes from not finishing what they've started." --David Allen
• "We forge the chains we wear in life." --Charles Dickens
• "If you look to others for fulfillment, you will never be fulfilled. If your happiness depends on money, you will never be happy with yourself. Be content with what you have; rejoice in the way things are. When you realize there is nothing lacking, the world belongs to you." --Lao Tzu
• "Everything is a gift of the universe--even joy, anger, jealousy, frustration, or separateness. Everything is perfect either for our growth or our enjoyment." --Ken Keyes Jr.
• "There is no such thing as a problem without a gift for you in its hands. You seek problems because you need their gifts." --Richard Bach
• "If you want to be happy, set a goal that commands your thoughts, liberates your energy, and inspires your hopes." --Andrew Carnegie
• "Tension is who you think you should be, relaxation is who you are." --Chinese proverb
• "For me it is sufficient to have a corner by my hearth, a book, and a friend, and a nap undisturbed by creditors or grief." --Fernandez de Andrada
• "You cannot judge what should bring others joy, and others cannot judge what should bring you joy." --Alan Cohen
• "The art of living lies less in eliminating our troubles than growing with them." --Bernard M. Baruch
• "Our capacity to draw happiness from aesthetic objects or material goods in fact seems critically dependent on our first satisfying a more important range of emotional or psychological needs, among them the need for understanding, for love, expression, and respect." --Alain de Botton
• "If you start to think the problem is 'out there,' stop yourself. That thought is the problem." --Stephen Covey
• "Happiness cannot be traveled to, owned, earned, worn, or consumed. Happiness is the spiritual experience of living every minute with love, grace, and gratitude." --Denis Waitley
• "Happiness is not a station you arrive at, but a manner of traveling." --Margaret Lee Runbeck
• "Security is when everything is settled, when nothing can happen to you; security is the denial of life." --Germaine Greer
• "Focus on the journey, not the destination. Joy is found not in finishing an activity but in doing it." --Greg Anderson
• "Thousands of candles can be lit from a single candle, and the life of the candle will not be shortened. Happiness never decreases by being shared." --Buddha
• "The best remedy for those who are afraid, lonely, or unhappy is to go outside, somewhere where they can be quiet, alone with the heavens, nature, and God. As long as this exists, and it certainly always will, then there will be comfort for every sorrow, whatever the circumstances may be." --Anne Frank
• "In our lives, change is unavoidable, loss is unavoidable. In the adaptability and ease with which we experience change, lies our happiness and freedom." --Buddha
• "Live with intention. Walk to the edge. Listen hard. Practice wellness. Play with abandon. Laugh. Choose with no regret. Do what you love. Live as if this is all there is." --Mary Anne Roadacher-Hershey
• "You never regret being kind." --Nicole Shepherd
• "They who can give up essential liberty to obtain a little temporary safety, deserve neither liberty nor safety." --Ben Franklin
• "Forgiveness does not change the past, but it does enlarge the future." --Paul Boese
• "The secret of health for both mind and body is not to mourn for the past, worry about the future, or anticipate troubles, but to live in the present moment wisely and earnestly." --Buddha
• "True happiness is not attained through self-gratification, but through fidelity to a worthy purpose." --Helen Keller
• "Money is neither my god nor my devil. It is a form of energy that tends to make us more of who we already are, whether it's greedy or loving." --Dan Millman
• "The need for forgiveness is an illusion. There is nothing to forgive." --Rachel England
• "Blessed are those who can give without remembering and take without forgetting." --Bernard Meltzer
• "Reflect upon your present blessings, of which every man has many--not on your past misfortunes, of which all men have some." --Charles Dickens
• "Even a happy life cannot be without a measure of darkness, and the word happy would lose its meaning if it were not balanced by sadness. It is far better to take things as they come along with patience and equanimity." --Carl Jung
• "He who lives in harmony with himself lives in harmony with the universe." --Marcus Aurelius
• "If you want others to be happy, practice compassion. If you want to be happy, practice compassion." --Dalai Lama
• "When one door of happiness closes, another opens, but often we look so long at the closed door that we do not see the one that has been opened for us." --Helen Keller
• "Happiness is not having what you want. It is appreciating what you have." --Unknown
• "True happiness ... arises, in the first place, from the enjoyment of one's self." --Joseph Addison
• "Happiness is that state of consciousness which proceeds from the achievement of one's values." --Ayn Rand
• "Most of us are just about as happy as we make up our minds to be." --William Adams
• "Success is getting what you want. Happiness is wanting what you get." --Dale Carnegie
• "We can have peace if we let go of wanting to change the past and wanting to control the future." --Lester Levinson
• "We make a living by what we get; we make a life by what we give." --Winston Churchill
• "Money doesn't bring happiness and creativity. Your creativity and happiness bring money." --Sam Rosen
• "Happiness is the experience of loving life. Being happy is being in love with that momentary experience. And love is looking at someone or even something and seeing the absolute best in him or her or it. Love is happiness with what you see. So love and happiness really are the same thing ... just expressed differently." --Robert McPhillips
• "Everything that irritates us about others can lead us to an understanding of ourselves." --Carl Jung
• "God, grant me the serenity to accept the things I cannot change, the courage to change the things I can, and the wisdom to know the difference." --Reinhold Niebuhr
• "I am not bound to win, I am bound to be true. I am not bound to succeed, but I am bound to live up to the light I have." --Abraham Lincoln
• "Gratitude unlocks the fullness of life. It turns what we have into enough and more. It turns denial into acceptance, chaos to order, confusion to clarity. It can turn a meal into a feast, a house into a home, a stranger into a friend. Gratitude makes sense of our past, brings peace for today, and creates a vision for tomorrow." --Melody Beattie
• "There is no stress in the world, only people thinking stressful thoughts and then acting on them." --Wayne Dyer
• "We all get report cards in many different ways, but the real excitement of what you're doing is in the doing of it. It's not what you're gonna get in the end--it's not the final curtain--it's really in the doing it, and loving what you're doing." --Ralph Lauren
• "In the midst of movement and chaos, keep stillness inside of you." --Deepak Chopra
• "Success at the highest level comes down to one question: Can you decide that your happiness can come from someone else's success?" --Bill Walton
• "There is only one thing more painful than learning from experience and that is not learning from experience." --Archibald MacLeish
• "Once you do something you love, you never have to work again." --Willie Hill
• "Anything in life that we don't accept will simply make trouble for us until we make peace with it." --Shakti Gawain
• "The right way is not always the popular and easy way. Standing for right when it is unpopular is a true test of moral character." --Margaret Chase Smith
• "Persons of high self-esteem are not driven to make themselves superior to others; they do not seek to prove their value by measuring themselves against a comparative standard. Their joy is being who they are, not in being better than someone else." --Nathaniel Branden
• "Anxiety is the dizziness of freedom." --Soren Kierkegaard
• "Do what you have always done and you'll get what you have always got." --Sue Knight
• "The happiness of life is made up of the little charities of a kiss or smile, a kind look, a heartfelt compliment." --Samuel Taylor Coleridge
• "We avoid the things that we're afraid of because we think there will be dire consequences if we confront them. But the truly dire consequences in our lives come from avoiding things that we need to learn about or discover." --Shakti Gawain
• "Think of what you have rather than of what you lack. Of the things you have, select the best and then reflect how eagerly you would have sought them if you did not have them." --Marcus Aurelius
• "Happiness is where we find it, but very rarely where we seek it." --J. Petit Senn
• "To be content means that you realize you contain what you seek." --Alan Cohen
• "The mind is its own place, and in itself can make a heaven of hell, a hell of heaven." --John Milton
• "In our daily lives, we must see that it is not happiness that makes us grateful, but the gratefulness that makes us happy." --Albert Clarke
• "Look at everything as though you were seeing it either for the first or last time. Then your time on earth will be filled with glory." --Betty Smith
• "You are responsible for your life. You can't keep blaming somebody else for your dysfunction. Life is really about moving on." --Oprah Winfrey
• "Expecting life to treat you well because you are a good person is like expecting an angry bull not to charge because you are a vegetarian." --Shari R. Barr
• "View your life from your funeral: Looking back at your life experiences, what have you accomplished? What would you have wanted to accomplish but didn't? What were the happy moments? What were the sad? What would you do again, and what wouldn't you do?" --Victor Frankl
• "Far better is it to dare mighty things, to win glorious triumphs--even though checkered by failure--than to rank with those poor spirits who neither enjoy much nor suffer much, because they live in a gray twilight that knows not victory nor defeat." --Theodore Roosevelt
• "Boredom is the feeling that everything is a waste of time ... serenity, that nothing is." --Thomas Szasz
• "To handle yourself, use your head; to handle others, use your heart." --Eleanor Roosevelt
• "The mediocre teacher tells. The good teacher explains. The superior teacher demonstrates. The great teacher inspires." --William Arthur Ward
• "It's hard to lead a cavalry charge if you think you look funny on a horse." --Adlai E. Stevenson II
• "Our chief want is someone who will inspire us to be what we know we could be." --Ralph Waldo Emerson
• "Keep your fears to yourself, but share your courage with others." --Robert Louis Stevenson
• "The greatest leader is not necessarily the one who does the greatest things. He is the one that gets people to do the greatest things." --Ronald Reagan
• "Only one man in a thousand is a leader of men--the other 999 follow women." Groucho Marx
• "Don't waste your energy trying to educate or change opinions; go over, under, through, and opinions will change organically when you're the boss. Or they won't. Who cares? Do your thing, and don't care if they like it." --Tina Fey
• "Power isn't control at all--power is strength, and giving that strength to others. A leader isn't someone who forces others to make him stronger; a leader is someone willing to give his strength to others that they may have the strength to stand on their own." --Beth Revis
• "Don't tell people how to do things; tell them what to do and let them surprise you with their results." --George S. Patton Jr.
• "I have three precious things which I hold fast and prize. The first is gentleness; the second is frugality; the third is humility, which keeps me from putting myself before others. Be gentle and you can be bold; be frugal and you can be liberal; avoid putting yourself before others and you can become a leader among men." --Lao Tzu
• "Leadership is the art of getting someone else to do something you want done because he wants to do it." --Dwight D. Eisenhower
• "Victory has a hundred fathers and defeat is an orphan." --John F. Kennedy
• "Management is doing things right; leadership is doing the right things." --Peter F. Drucker
• "You are not here merely to make a living. You are here in order to enable the world to live more amply, with greater vision, with a finer spirit of hope and achievement. You are here to enrich the world, and you impoverish yourself if you forget the errand." --Woodrow Wilson
• "Example is not the main thing in influencing others. It is the only thing." --Albert Schweitzer
• "Leaders must be close enough to relate to others, but far enough ahead to motivate them." --John C. Maxwell
• "The mark of a great man is one who knows when to set aside the important things in order to accomplish the vital ones." --Brandon Sanderson
• "Leadership is not about titles, positions, or flowcharts. It is about one life influencing another." --John C. Maxwell
• "You have to be burning with an idea, or a problem, or a wrong that you want to right. If you're not passionate enough from the start, you'll never stick it out." --Steve Jobs
• "A leader ... is like a shepherd. He stays behind the flock, letting the most nimble go out ahead, whereupon the others follow, not realizing that all along they are being directed from behind." --Nelson Mandela
• "Being responsible sometimes means pissing people off." --Colin Powell
• "Do you know that one of the great problems of our age is that we are governed by people who care more about feelings than they do about thoughts and ideas." --Margaret Thatcher
• "A leader is a dealer in hope." --Napoleon
• "The best executive is the one who has sense enough to pick good men to do what he wants done, and self-restraint to keep from meddling with them while they do it." --Theodore Roosevelt
• "I don't see myself being special; I just see myself having more responsibilities than the next man. People look to me to do things for them, to have answers." --Tupac Shakur
• "If you would convince a man that he does wrong, do right. But do not care to convince him. Men will believe what they see. Let them see." --Henry David Thoreau
• "I cannot trust a man to control others who cannot control himself." --Robert E. Lee
• "The day the soldiers stop bringing you their problems is the day you stopped leading them. They have either lost confidence that you can help them or concluded that you do not care. Either case is a failure of leadership." --Colin Powell
• "Consensus: the process of abandoning all beliefs, principles, values, and policies in search of something in which no one believes, but to which no one objects; the process of avoiding the very issues that have to be solved, merely because you cannot get agreement on the way ahead. What great cause would have been fought and won under the banner: 'I stand for consensus?'" --Margaret Thatcher
• "A leader takes people where they want to go. A great leader takes people where they don't necessarily want to go but ought to be." --Rosalynn Carter
• "There is a difference between being a leader and being a boss. Both are based on authority. A boss demands blind obedience; a leader earns his authority through understanding and trust." --Klaus Balkenhol
• "You get in life what you have the courage to ask for." --Nancy D. Solomon
• "In the end, it is important to remember that we cannot become what we need to be by remaining what we are." --Max De Pree
• "We're here for a reason. I believe a bit of the reason is to throw little torches out to lead people through the dark." --Whoopi Goldberg
• "A leader isn't someone who forces others to make him stronger; a leader is someone willing to give his strength to others so that they may have the strength to stand on their own." --Beth Revis
• "Always remember, son, the best boss is the one who bosses the least. Whether it's cattle, or horses, or men, the least government is the best government." --Ralph Moody
• "If you really want the key to success, start by doing the opposite of what everyone else is doing." --Brad Szollose
• "'Give as few orders as possible,' his father had told him once long ago. 'Once you've given orders on a subject, you must always give orders on that subject.'" --Frank Herbert (from Dune)
• "The art of leadership is saying no, not yes. It is very easy to say yes." --Tony Blair
• "Wisdom equals knowledge plus courage. You have to not only know what to do and when to do it, but you have to also be brave enough to follow through." --Jarod Kintz
• "In a battle between two ideas, the best one doesn't necessarily win. No, the idea that wins is the one with the most fearless heretic behind it." --Seth Godin
• "Remember, teamwork begins by building trust. And the only way to do that is to overcome our need for invulnerability." --Patrick Lencioni
• "No guts, no story." --Chris Brady
• "Leadership is an action, not a position." --Donald McGannon
• "Surround yourself with great people; delegate authority; get out of the way." --Ronald Reagan
• "I cannot give you a formula for success, but I can give you the formula for failure, which is: Try to please everybody." --Herbert Bayard Swope
• "Show me the man you honor and I will know what kind of man you are." --Thomas John Carlisle
• "The challenge of leadership is to be strong but not rude; be kind but not weak; be bold but not a bully; be humble but not timid; be proud but not arrogant; have humor but without folly." --Jim Rohn
• "A man always has two reasons for doing anything: a good reason and the real reason." --J.P. Morgan
• "If you spend your life trying to be good at everything, you will never be great at anything." --Tom Rath
• "Average leaders raise the bar on themselves; good leaders raise the bar for others; great leaders inspire others to raise their own bar." --Orrin Woodward
• "Don't blow off another's candle, for it won't make yours shine brighter." --Jaachynma N.E. Agu
• "Whenever you see a successful business, someone once made a courageous decision." --Peter F. Drucker
• "When you put together deep knowledge about a subject that intensely matters to you, charisma happens. You gain courage to share your passion, and when you do that, folks follow." --Jerry Porras
• "A good leader leads the people from above them. A great leader leads the people from within them." --M.D. Arnold
• "The ultimate measure of a man is not where he stands in moments of comfort, but where he stands at times of challenge and controversy." --Martin Luther King Jr.
• "The very essence of leadership is that you have to have vision. You can't blow an uncertain trumpet." --Father Theodore M. Hesburgh
• "It is absolutely necessary ... for me to have persons that can think for me, as well as execute orders." --George Washington
• "When eagles are silent, parrots begin to chatter." --Winston Churchill
• "A leader takes people where they would never go on their own." --Hans Finzel
• "You don't lead by pointing and telling people some place to go. You lead by going to that place and making a case." --Ken Kesey
• "A man who wants to lead the orchestra must turn his back on the crowd." --Max Lucado
• "Become the kind of leader that people would follow voluntarily, even if you had no title or position." --Brian Tracy
• "I start with the premise that the function of leadership is to produce more leaders, not more followers." --Ralph Nader
• "Anyone can hold the helm when the sea is calm." --Publilius Syrus
• "A great person attracts great people and knows how to hold them together." --Johann Wolfgang von Goethe
• "My job is not to be easy on people. My job is to take these great people we have and to push them and make them even better." --Steve Jobs
• "People buy into the leader before they buy into the vision." --John Maxwell
• "To have long-term success as a coach or in any position of leadership, you have to be obsessed in some way." --Pat Riley
• "A good leader is a person who takes a little more than his share of the blame and a little less than his share of the credit." --John Maxwell
• "A good plan violently executed now is better than a perfect plan executed next week." --George Patton
• "Earn your leadership every day." --Michael Jordan
• "Feeling gratitude and not expressing it is like wrapping a present and not giving it." --William Arthur Ward
• "I would maintain that thanks are the highest form of thought; and that gratitude is happiness doubled by wonder." --G.K. Chesterton
• "'Enough' is a feast." --Buddhist proverb
• "If you count all your assets, you always show a profit." --Robert Quillen
• "Enjoy the little things, for one day you may look back and realize they were the big things." --Robert Brault
• "As we express our gratitude, we must never forget that the highest appreciation is not to utter words but to live by them." --John F. Kennedy
• "Acknowledging the good that you already have in your life is the foundation for all abundance." --Eckhart Tolle
• "If a fellow isn't thankful for what he's got, he isn't likely to be thankful for what he's going to get." --Frank A. Clark
• "If you want to turn your life around, try thankfulness. It will change your life mightily." --Gerald Good
• "Gratitude turns what we have into enough and more. It turns denial into acceptance, chaos into order, confusion into clarity ... it makes sense of our past, brings peace for today, and creates a vision for tomorrow." --Melody Beattie
• "The world has enough beautiful mountains and meadows, spectacular skies and serene lakes. It has enough lush forests, flowered fields, and sandy beaches. It has plenty of stars and the promise of a new sunrise and sunset every day. What the world needs more of is people to appreciate and enjoy it." --Michael Josephson
• "Gratitude is a currency that we can mint for ourselves, and spend without fear of bankruptcy." --Fred De Witt Van Amburgh
• "The way to develop the best that is in a person is by appreciation and encouragement." --Charles Schwab
• "He is a wise man who does not grieve for the things which he has not, but rejoices for those which he has." --Epictetus
• "At times, our own light goes out and is rekindled by a spark from another person. Each of us has cause to think with deep gratitude of those who have lighted the flame within us." --Albert Schweitzer
• "The deepest craving of human nature is the need to be appreciated." --William James
• "Be thankful for what you have; you'll end up having more. If you concentrate on what you don't have, you will never, ever have enough." --Oprah Winfrey
• "Let us rise up and be thankful, for if we didn't learn a lot today, at least we learned a little, and if we didn't learn a little, at least we didn't get sick, and if we got sick, at least we didn't die; so, let us all be thankful." --Buddha
• "Silent gratitude isn't very much to anyone." --Gertrude Stein
• "Thankfulness is the beginning of gratitude. Gratitude is the completion of thankfulness. Thankfulness may consist merely of words. Gratitude is shown in acts." --Henri Frederic Amiel
• "You cannot do a kindness too soon, because you never know how soon it will be too late." --Ralph Waldo Emerson
• "It is impossible to feel grateful and depressed in the same moment." --Naomi Williams
• "One can never pay in gratitude; one can only pay 'in kind' somewhere else in life." --Anne Morrow Lindbergh
• "Things turn out best for people who make the best of the way things turn out." --John Wooden
• "No one who achieves success does so without the help of others. The wise and confident acknowledge this help with gratitude." --Alfred North Whitehead
• "Piglet noticed that even though he had a Very Small Heart, it could hold a rather large amount of Gratitude." --A.A. Milne
• "Forget yesterday--it has already forgotten you. Don't sweat tomorrow--you haven't even met. Instead, open your eyes and your heart to a truly precious gift--today." --Steve Maraboli
• "We should certainly count our blessings, but we should also make our blessings count." --Neal A. Maxwell
• "In ordinary life, we hardly realize that we receive a great deal more than we give, and that it is only with gratitude that life becomes rich." --Dietrich Bonhoeffer
• "The only people with whom you should try to get even are those who have helped you." --John E. Southard
• "I truly believe we can either see the connections, celebrate them, and express gratitude for our blessings, or we can see life as a string of coincidences that have no meaning or connection. For me, I'm going to believe in miracles, celebrate life, rejoice in the views of eternity, and hope my choices will create a positive ripple effect in the lives of others. This is my choice." --Mike Ericksen
• "Gratitude also opens your eyes to the limitless potential of the universe, while dissatisfaction closes your eyes to it." --Stephen Richards
• "Gratitude and attitude are not challenges; they are choices." --Robert Braathe
• "They both seemed to understand that describing it was beyond their powers, the gratitude that spreads through your body when a burden gets lifted, and the sense of homecoming that follows, when you suddenly remember what it feels like to be yourself." --Tom Perrotta
• "Gratitude is more of a compliment to yourself than someone else." --Raheel Farooq
• "Keep your eyes open and try to catch people in your company doing something right, then praise them for it." --Tom Hopkins
• "In life, one has a choice to take one of two paths: to wait for some special day--or to celebrate each special day." --Rasheed Ogunlaru
• "This a wonderful day. I've never seen this one before." --Maya Angelou
• "The way to develop self-confidence is to do the thing you fear and get a record of successful experiences behind you." --William Jennings Bryan
• "If you hear a voice within you say, 'You cannot paint,' then by all means paint, and that voice will be silenced." --Vincent van Gogh
• "Always be yourself and have faith in yourself. Do not go out and look for a successful personality and try to duplicate it." --Bruce Lee
• "Don't wait until everything is just right. It will never be perfect. There will always be challenges, obstacles, and less than perfect conditions. So what? Get started now. With each step you take, you will grow stronger and stronger, more and more skilled, more and more self-confident, and more and more successful." --Mark Victor Hansen
• "You wouldn't worry so much about what others think of you if you realized how seldom they do." --Eleanor Roosevelt
• "Low self-confidence isn't a life sentence. Self-confidence can be learned, practiced, and mastered--just like any other skill. Once you master it, everything in your life will change for the better." --Barrie Davenport
• "Once we believe in ourselves, we can risk curiosity, wonder, spontaneous delight, or any experience that reveals the human spirit." e. e. cummings
• "Trust yourself. Create the kind of self that you will be happy to live with all your life. Make the most of yourself by fanning the tiny, inner sparks of possibility into flames of achievement." Golda Meir
• "One important key to success is self-confidence. An important key to self-confidence is preparation." --Arthur Ashe
• "It is confidence in our bodies, minds, and spirits that allows us to keep looking for new adventures." --Oprah Winfrey
• "To be yourself in a world that is constantly trying to make you something else is the greatest accomplishment." --Ralph Waldo Emerson
• "But failure has to be an option in art and in exploration--because it's a leap of faith. And no important endeavor that required innovation was done without risk. You have to be willing to take those risks ... " --James Cameron
• "People are like stained-glass windows. They sparkle and shine when the sun is out, but when the darkness sets in their true beauty is revealed only if there is light from within." --Elisabeth Kübler-Ross
• "Confidence comes not from always being right but from not fearing to be wrong." --Peter T. Mcintyre
• "Argue for your limitations and, sure enough, they're yours." --Richard Bach
• "The courage to be is the courage to accept oneself, in spite of being unacceptable." --Paul Tillich
• "If we all did the things we are capable of doing, we would literally astound ourselves." --Thomas Alva Edison
• "Shyness has a strange element of narcissism, a belief that how we look, how we perform, is truly important to other people." --Andre Dubus
• "Our deepest fear is not that we are inadequate. Our deepest fear is that we are powerful beyond measure. It is our light, not our darkness, that most frightens us. We ask ourselves, 'Who am I to be brilliant, gorgeous, talented, fabulous?' Actually, who are you not to be?" --Marianne Williamson
• "Talk to yourself like you would to someone you love." --Brené Brown
• "Trust yourself. You know more than you think you do." --Dr. Benjamin Spock
• "Successful people have fear, successful people have doubts, and successful people have worries. They just don't let these feelings stop them." --T. Harv Eker
• "You can have anything you want if you are willing to give up the belief that you can't have it." --Dr. Robert Anthony
• "It is not the mountain we conquer, but ourselves." --Sir Edmund Hillary
• "To love oneself is the beginning of a lifelong romance." --Oscar Wilde
• "You yourself, as much as anyone in the entire universe, deserve your love and affection." --Buddha
• "Inaction breeds doubt and fear. Action breeds confidence and courage. If you want to conquer fear, do not sit home and think about it. Go out and get busy." --Dale Carnegie
• "Optimism is the faith that leads to achievement. Nothing can be done without hope and confidence." --Helen Keller
• "Nothing can stop the man with the right mental attitude from achieving his goal; nothing on earth can help the man with the wrong mental attitude." --Thomas Jefferson
• "Confidence is a habit that can be developed by acting as if you already had the confidence you desire to have." --Brian Tracy
• "If you are insecure, guess what? The rest of the world is too. Do not overestimate the competition and underestimate yourself. You are better than you think." --T. Harv Eker
• "Wouldn't it be powerful if you fell in love with yourself so deeply that you would do just about anything if you knew it would make you happy? This is precisely how much life loves you and wants you to nurture yourself. The deeper you love yourself, the more the universe will affirm your worth. Then you can enjoy a lifelong love affair that brings you the richest fulfillment from inside out." --Alan Cohen
• "To anyone that ever told you you're no good ... They're no better." --Hayley Williams
• "Always remember you are braver than you believe, stronger than you seem, and smarter than you think." --Christopher Robin
• "You have no control over other people's taste, so focus on staying true to your own." --Tim Gunn
• "No one can make you feel inferior without your consent." --Eleanor Roosevelt
• "The moment you doubt whether you can fly, you cease forever to be able to do it." --J.M. Barrie
• "It's a dead-end street if you sit around waiting for someone else to tell you you're OK." --Michael Pitt
• "I think that the power is the principle. The principle of moving forward, as though you have the confidence to move forward, eventually gives you confidence when you look back and see what you've done." --Robert Downey Jr.
• "Don't be satisfied with stories, how things have gone with others. Unfold your own myth." --Rumi
• "When you're different, sometimes you don't see the millions of people who accept you for what you are. All you notice is the person who doesn't." --Jodi Picoult
• "As soon as you trust yourself, you will know how to live." --Johann Wolfgang von Goethe
• "You cannot be lonely if you like the person you're alone with." --Dr. Wayne Dyer
• "Pride is holding your head up when everyone around you has theirs bowed. Courage is what makes you do it." --Bryce Courtenay
• "I attribute my success to this: I never gave or took any excuse." --Florence Nightingale
• "The most difficult thing is the decision to act; the rest is merely tenacity." --Amelia Earhart
• "Do it or not. There is no try." --Yoda
• "When I let go of what I am, I become what I might be." --Lao Tzu
• "The most common way people give up their power is by thinking they don't have any." --Alice Walker
• "Life is what happens to you while you're busy making other plans." --John Lennon
• "Eighty percent of success is showing up." --Woody Allen
• "It is never too late to be what you might have been." --George Eliot
• "When everything seems to be going against you, remember that the airplane takes off against the wind, not with it." --Henry Ford
• "You can't fall if you don't climb. But there's no joy in living your whole life on the ground." --Unknown
• "Challenges are what make life interesting and overcoming them is what makes life meaningful." --Joshua Marine
• "If you want to lift yourself up, lift up someone else." --Booker T. Washington
• "Rarely have I seen a situation where doing less than the other guy is a good strategy." --Jimmy Spithill
• "Your time is limited, so don't waste it living someone else's life." --Steve Jobs
• "I am not a product of my circumstances. I am a product of my decisions." --Stephen Covey
• "The two most important days in your life are the day you are born and the day you find out why." --Mark Twain
• "Whatever you can do, or dream you can, begin it. Boldness has genius, power, and magic in it." --Johann Wolfgang von Goethe
• "Life shrinks or expands in proportion to one's courage." --Anais Nin
• "There is only one way to avoid criticism: Do nothing, say nothing, and be nothing." --Aristotle
• "Do what you can, where you are, with what you have." --Theodore Roosevelt
• "Everything you've ever wanted is on the other side of fear." --George Addair
• "Fall seven times and stand up eight." --Japanese proverb
• "Two roads diverged in a wood, and I, I took the one less traveled by, and that has made all the difference." --Robert Frost
• "The extra mile is a vast, unpopulated wasteland." (OK, that one's mine)
• "What's money? A man is a success if he gets up in the morning and goes to bed at night and in between does what he wants to do." --Bob Dylan
• "A person who never made a mistake never tried anything new." --Albert Einstein
• "The person who says it cannot be done should not interrupt the person who is doing it." --Chinese proverb
• "You can't use up creativity. The more you use, the more you have." --Maya Angelou
• "You miss 100 percent of the shots you don't take." --Wayne Gretzky
• "Build your own dreams, or someone else will hire you to build theirs." --Farrah Gray
• "It does not matter how slowly you go as long as you do not stop." --Confucius
• "If you do what you've always done, you'll get what you've always gotten." --Tony Robbins
• "You may be disappointed if you fail, but you are doomed if you don't try." --Beverly Sills
• "Few things can help an individual more than to place responsibility on him, and to let him know that you trust him." --Booker T. Washington
• "The question isn't who is going to let me; it's who is going to stop me." --Ayn Rand
• "The only way to do great work is to love what you do." --Steve Jobs